High Cholesterol Medication in Singapore

Medication is recommended when lifestyle measures like diet and exercise are not enough to bring cholesterol to safe levels. Common reasons include persistently high LDL (“bad”) cholesterol, family history of heart disease, diabetes, high blood pressure, or multiple cardiovascular risk factors.

Our doctors prescribe a range of evidence-based medications, including:

• Statins (e.g. atorvastatin, rosuvastatin, simvastatin) – the most common first-line treatment.
• Cholesterol absorption inhibitors (e.g. ezetimibe) – often used with statins for added effect.
• PCSK9 inhibitors – injectable therapy for patients at very high cardiovascular risk or unable to tolerate statins.
• Fibrates and other agents – mainly for lowering triglycerides and raising HDL (“good”) cholesterol.

Statins are well studied and widely prescribed worldwide. They effectively reduce the risk of heart attack and stroke. Some patients may experience muscle aches, mild liver enzyme changes, or digestive issues, but these are uncommon and usually manageable with monitoring or dose adjustments.

A typical visit includes:

• Lipid blood test – fasting or non-fasting profile
• Doctor review – assessment of your risk factors, family history, lifestyle, and current medications
• Treatment plan – which may include lifestyle changes, prescription medication, and a monitoring schedule (e.g. repeat tests every 3–6 months)

It depends on the medication type. Some statins (like simvastatin) work best at night, while others (like atorvastatin or rosuvastatin) can be taken at any time of the day. Our doctor will provide clear instructions tailored to your prescription.

Most cholesterol medications begin lowering cholesterol within 4–6 weeks. Our doctor will usually recommend a repeat blood test after 3 months to monitor effectiveness and adjust treatment if needed.

If you forget a dose, take it as soon as you remember unless it is almost time for your next scheduled dose. Do not double up. If you are unsure, consult your doctor for advice.

Moderate alcohol intake is generally safe for most patients. However, excessive drinking can increase the risk of liver side effects, especially with statins. Always discuss your alcohol intake with your doctor to ensure it is safe with your prescribed medication.

Yes. Some medications, including certain antibiotics, antifungals, and heart drugs, may interact with statins and other cholesterol medicines. Always inform our doctor of all medications and supplements you are taking to avoid harmful interactions.

Grapefruit and grapefruit juice can interact with certain statins and should be avoided. Beyond this, a heart-healthy diet low in saturated fats and high in fibre is recommended to maximise the benefits of treatment.

Follow-up blood tests are typically done 3 months after starting or changing medication, then every 6–12 months once levels are stable. Our doctor may adjust this schedule depending on your overall health and cardiovascular risk.

Yes. For most patients, long-term use of statins and other lipid-lowering drugs is safe and significantly reduces cardiovascular risk. Our doctor will monitor for side effects and adjust therapy as needed.

Many patients need long-term treatment, but some may reduce or stop medication if sustained lifestyle changes lead to major improvements in cholesterol. Regular monitoring and medical review are essential before making any changes.

No. All cholesterol-lowering medications in Singapore require a doctor’s consultation and prescription. This ensures safety, correct dosage, and monitoring for side effects.