HPV DNA Self-Sampling
by: Dr. Tan Hue Min, General Practitioner, Regis Medical
A Convenient and Reliable Cervical Cancer Screening Option at Regis Medical
Cervical cancer remains a significant global health concern, with an estimated 570,000 new cases and 311,000 deaths worldwide in 2018 alone (1). Fortunately, advancements in screening and early detection, including a new method of self-sampling to test for HPV, have made this disease largely preventable and treatable. At Regis Medical, we're dedicated to providing women in Singapore with the most innovative and accessible options for cervical cancer screening, including HPV DNA self-sampling.
Understanding HPV and Cervical Cancer
Human Papillomavirus (HPV) is a common virus, with most sexually active adults contracting at least one type in their lifetime. While most HPV infections clear up on their own, persistent infection with certain high-risk types (such as 16 and 18) can lead to cellular changes in the cervix. These cellular changes, if left undetected and untreated, may progress to cervical cancer.
HPV DNA Self-Sampling: Empowering Women
HPV DNA self-sampling is a new approach to cervical cancer screening that allows women to collect their own cervical cells for HPV testing. This method offers a comfortable and convenient alternative to traditional Pap smears, which require a speculum examination by a healthcare professional.
How Does it Work?
The process is simple and discreet. You'll be provided with a kit containing clear instructions and all the necessary materials. The collection process involves gently inserting a small device into the vagina to collect cells from the cervix, or using fluid to flush cells out for sampling. The sample is then sealed in a container and sent to a laboratory for analysis.
Benefits of HPV DNA Self-Sampling:
- Increased comfort and privacy: Many women find the self-sampling method less invasive and more comfortable than a traditional Pap smear.
- Improved accessibility: Self-sampling can overcome barriers to screening, such as geographical distance, limited access to healthcare facilities, and cultural sensitivities. Research indicates that offering self-sampling can increase screening uptake by up to 20% (2).
- High accuracy: Studies have shown that HPV DNA self-sampling is as accurate as a Pap smear in detecting high-risk HPV infections (3). In fact, some studies suggest that self-sampling is probably as sensitive in detecting precancerous lesions (4).
- Early detection: By detecting high-risk HPV infections early, even before any cellular changes occur, self-sampling enables timely intervention and management, significantly reducing the risk of cervical cancer.
Who Should Consider HPV DNA Self-Sampling?
HPV DNA self-sampling is generally recommended for women:
- Aged 30 and above: This is the age group where cervical cancer risk starts to increase significantly.
- Who are overdue for their Pap smear: Self-sampling offers a convenient way to catch up on cervical cancer screening.
- Who experience discomfort or anxiety during Pap smears: Self-sampling provides a more comfortable alternative.
What Happens After the Test?
Our laboratory will analyse your sample for the presence of high-risk HPV types. You will receive your results within a few days. If your result is positive for high-risk HPV, our healthcare professionals will discuss the next steps, which may include further testing or monitoring, or referral to a Gynaecologic specialist.
Important Note:
While HPV DNA self-sampling is a valuable tool for cervical cancer screening, it is important to remember that it is not a replacement for regular check-ups with your doctor.
Take Control of Your Cervical Health
Regis Medical is dedicated to empowering women with knowledge and choices when it comes to their health. HPV DNA self-sampling is a safe, effective, and convenient option for cervical cancer screening. Contact us today to learn more about this innovative approach and take a proactive step towards protecting your health.
Screen for Cervical Cancer with Regis Medical HPV DNA Self-Samping
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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Giorgi Rossi, P., Fortunato, C., Barbarino, P., Boveri, S., Caroli, S., Del Mistro, A., Ferro, A., Giammaria, C., Manfredi, M., Moretto, T., Pasquini, A., Sideri, M., Tufi, M. C., Cogo, C., Altobelli, E., & HPV Self-sampling Italian Working Group (2015). Self-sampling to increase participation in cervical cancer screening: an RCT comparing home mailing, distribution in pharmacies, and recall letter. British journal of cancer, 112(4), 667–675. Martinelli, M., Giubbi, C., Di Meo, M. L., Perdoni, F., Musumeci, R., Leone, B. E., Fruscio, R., Landoni, F., & Cocuzza, C. E. (2023). Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy. Viruses, 15(9), 1889.
Arbyn M, Verdoodt F, Snijders PJF, et al. Accuracy of human papillomavirus testing on self-collected versus clinician-collected samples: a meta-analysis. Lancet Oncol. 2014;15(2):172-183.
Szarewski, A., Cadman, L., Mesher, D., Austin, J., Ashdown-Barr, L., Edwards, R., Lyons, D., Walker, J., Christison, J., Frater, A., & Waller, J. (2011). HPV self-sampling as an alternative strategy in non-attenders for cervical screening - a randomised controlled trial. British journal of cancer, 104(6), 915–920.
Igidbashian, S., Boveri, S., Spolti, N., Radice, D., Sandri, M. T., & Sideri, M. (2011). Self-collected human papillomavirus testing acceptability: comparison of two self-sampling modalities. Journal of women's health (2002), 20(3), 397–402.
Castell, S., Krause, G., Schmitt, M., Pawlita, M., Deleré, Y., Obi, N., Flesch-Janys, D., Kemmling, Y., & Kaufmann, A. M. (2014). Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2). Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 57(11), 1270–1276. (This featured an example of self sampling, the Delphi Screener* in a national screening programme)
